MovDisordV3, Main, Exploration, bibRecord, 000490

Onset of Huntington disease: Can it be purely cognitive?

Identifieur interne : 000490 ( Main/Exploration ); précédent : 000489; suivant : 000491

Onset of Huntington disease: Can it be purely cognitive?

Auteurs : Jane S. Paulsen [États-Unis] ; Jeffrey D. Long [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.

RBID : PMC:4193504

English descriptors

KwdEn :
- Adult, Cognition Disorders (diagnosis), Cognition Disorders (etiology), Female, Humans, Huntington Disease (complications), Huntington Disease (genetics), Longitudinal Studies, Male, Middle Aged, Nerve Tissue Proteins (genetics), Neuropsychological Tests, Severity of Illness Index, Trinucleotide Repeat Expansion (genetics).
MESH :
- chemical , genetics : Nerve Tissue Proteins.
- complications : Huntington Disease.
- diagnosis : Cognition Disorders.
- etiology : Cognition Disorders.
- genetics : Huntington Disease, Trinucleotide Repeat Expansion.
- Adult, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index.

Abstract

Knowledge of the cognitive manifestation of Huntington disease has burgeoned over the past two decades. Many studies from independent datasets have shown cognitive impairment is evident prior to motor diagnosis and annual cognitive decline is a robust marker of disease progression. Additionally, cognition is a critical concern to patients and families and is associated with meaningful outcomes including functional capacity, driving, loss of accustomed work and quality of life. In the past few years, Huntington disease animal models of cognition have increased, preparing for preclinical experimental therapeutics with cognitive endpoints. A longitudinal analysis of cognitive variables was conducted with 559 gene-positive cases and 233 controls showing no signs of motor abnormalities over approximately a three year period. Results show there were statistically significant differences in rate of annual change for some cognitive variables, such that the cases group had worsening performance over time. These findings show cognitive deterioration can be seen in persons with the Huntington disease gene expansion with no overt motor signs or symptoms, suggesting that cognitive onset of Huntington disease may precede motor.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193504

DOI: 10.1002/mds.25997
PubMed: 25142616
PubMed Central: 4193504

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Onset of Huntington disease: Can it be purely cognitive?</title>
<author><name sortKey="Paulsen, Jane S" sort="Paulsen, Jane S" uniqKey="Paulsen J" first="Jane S." last="Paulsen">Jane S. Paulsen</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Carver College of Medicine, The University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A3">Department of Psychology, The University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychology, The University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author><name sortKey="Long, Jeffrey D" sort="Long, Jeffrey D" uniqKey="Long J" first="Jeffrey D." last="Long">Jeffrey D. Long</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A4">Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25142616</idno>
<idno type="pmc">4193504</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193504</idno>
<idno type="RBID">PMC:4193504</idno>
<idno type="doi">10.1002/mds.25997</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000414</idno>
<idno type="wicri:Area/Pmc/Curation">000414</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000021</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000418</idno>
<idno type="wicri:Area/PubMed/Curation">000418</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000497</idno>
<idno type="wicri:Area/Ncbi/Merge">004085</idno>
<idno type="wicri:Area/Ncbi/Curation">004085</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004085</idno>
<idno type="wicri:doubleKey">0885-3185:2014:Paulsen J:onset:of:huntington</idno>
<idno type="wicri:Area/Main/Merge">000490</idno>
<idno type="wicri:Area/Main/Curation">000490</idno>
<idno type="wicri:Area/Main/Exploration">000490</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Onset of Huntington disease: Can it be purely cognitive?</title>
<author><name sortKey="Paulsen, Jane S" sort="Paulsen, Jane S" uniqKey="Paulsen J" first="Jane S." last="Paulsen">Jane S. Paulsen</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Carver College of Medicine, The University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A3">Department of Psychology, The University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychology, The University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author><name sortKey="Long, Jeffrey D" sort="Long, Jeffrey D" uniqKey="Long J" first="Jeffrey D." last="Long">Jeffrey D. Long</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A4">Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Cognition Disorders (diagnosis)</term>
<term>Cognition Disorders (etiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Huntington Disease (complications)</term>
<term>Huntington Disease (genetics)</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nerve Tissue Proteins (genetics)</term>
<term>Neuropsychological Tests</term>
<term>Severity of Illness Index</term>
<term>Trinucleotide Repeat Expansion (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nerve Tissue Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Huntington Disease</term>
<term>Trinucleotide Repeat Expansion</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Severity of Illness Index</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Knowledge of the cognitive manifestation of Huntington disease has burgeoned over the past two decades. Many studies from independent datasets have shown cognitive impairment is evident prior to motor diagnosis and annual cognitive decline is a robust marker of disease progression. Additionally, cognition is a critical concern to patients and families and is associated with meaningful outcomes including functional capacity, driving, loss of accustomed work and quality of life. In the past few years, Huntington disease animal models of cognition have increased, preparing for preclinical experimental therapeutics with cognitive endpoints. A longitudinal analysis of cognitive variables was conducted with 559 gene-positive cases and 233 controls showing no signs of motor abnormalities over approximately a three year period. Results show there were statistically significant differences in rate of annual change for some cognitive variables, such that the cases group had worsening performance over time. These findings show cognitive deterioration can be seen in persons with the Huntington disease gene expansion with no overt motor signs or symptoms, suggesting that cognitive onset of Huntington disease may precede motor.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Iowa</li>
</region>
<settlement><li>Iowa City</li>
</settlement>
<orgName><li>Université de l'Iowa</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Iowa"><name sortKey="Paulsen, Jane S" sort="Paulsen, Jane S" uniqKey="Paulsen J" first="Jane S." last="Paulsen">Jane S. Paulsen</name>
</region>
<name sortKey="Long, Jeffrey D" sort="Long, Jeffrey D" uniqKey="Long J" first="Jeffrey D." last="Long">Jeffrey D. Long</name>
<name sortKey="Long, Jeffrey D" sort="Long, Jeffrey D" uniqKey="Long J" first="Jeffrey D." last="Long">Jeffrey D. Long</name>
<name sortKey="Paulsen, Jane S" sort="Paulsen, Jane S" uniqKey="Paulsen J" first="Jane S." last="Paulsen">Jane S. Paulsen</name>
<name sortKey="Paulsen, Jane S" sort="Paulsen, Jane S" uniqKey="Paulsen J" first="Jane S." last="Paulsen">Jane S. Paulsen</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000490 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000490 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4193504
   |texte=   Onset of Huntington disease: Can it be purely cognitive?
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25142616" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a MovDisordV3

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Onset of Huntington disease: Can it be purely cognitive?

Onset of Huntington disease: Can it be purely cognitive?

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.